Predictable patterns of CTL escape and reversion across host populations and viral subtypes in HIV-1 evolution

نویسندگان

  • Duncan S. Palmer
  • Emily Adland
  • John A. Frater
  • Philip J.R. Goulder
  • Thumbi Ndung'u
  • Philippa C. Matthews
  • Rodney E. Phillips
  • Roger Shapiro
  • Gil McVean
  • Angela R. McLean
چکیده

1Department of Statistics, 1 South Parks Road, University of Oxford, Oxford OX1 3TG, UK 2Institute for Emerging Infections, The Oxford Martin School, Oxford OX1 3BD, UK 3Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK 4Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK 5Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, UK 6Oxford NIHR Biomedical Research Centre, Oxford OX3 7LE, UK 7HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, 4013 South Africa 8Botswana Harvard AIDS Institute Partnership, Gaborone BO 320, Botswana 9Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02215 10Zoology Department, South Parks Road, University of Oxford, Oxford OX1 3PS, UK

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Modelling the Evolution and Spread of HIV Immune Escape Mutants

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Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703–positive individuals and their transmission recipients

HLA-B*57 is the class I allele most consistently associated with control of human immunodeficiency virus (HIV) replication, which may be linked to the specific HIV peptides that this allele presents to cytotoxic T lymphocytes (CTLs), and the resulting efficacy of these cellular immune responses. In two HIV C clade-infected populations in South Africa and Zambia, we sought to elucidate the role ...

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Low level of HIV-1 evolution after transmission from mother to child

Mother-to-child HIV-1 transmission pairs represent a good opportunity to study the dynamics of CTL escape and reversion after transmission in the light of shared and non-shared HLA-alleles. Mothers share half of their HLA alleles with their children, while the other half is inherited from the father and is generally discordant between mother and child. This implies that HIV-1 transmitted from m...

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HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations

BACKGROUND Cytotoxic T-Lymphocyte (CTL) response drives the evolution of HIV-1 at a host-level by selecting HLA-restricted escape mutations. Dissecting the dynamics of these escape mutations at a population-level would help to understand how HLA-mediated selection drives the evolution of HIV-1. METHODOLOGY/PRINCIPAL FINDINGS We undertook a study of the dynamics of HIV-1 CTL-escape mutations b...

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تاریخ انتشار 2015